Tullia Carmela Bruno

Dendritic cells type 1 control the formation, maintenance, and function of tertiary lymphoidstructures in cancer

This study identifies the role of mature dendritic cells type 1 in forming, maintaining, and functioning tertiary lymphoid structures in cancer.

Integrative multi-omic analysis identifies tumor-intrinsic p38 as a driver of immune exclusion in human epithelial cancers

This study identifies tumor-intrinsic p38 activation as a driver of immune exclusion in epithelial cancers and suggests it as a therapeutic target to overcome immunotherapy resistance.

IFNγ-dependent metabolic reprogramming restrains an immature, pro-metastatic lymphatic state in melanoma

This study shows that IFNγ suppresses lymphatic vessel growth and metastasis by altering metabolism and immune function in melanoma.

SARC028 samples reveal an interplay between TGF-beta, interferon signaling and low HLA class I expression as contributors to Ewing sarcoma checkpoint blockade resistance

The paper analyzes paired tumor biopsies from Ewing sarcoma patients before and after pembrolizumab therapy to identify features of resistance to checkpoint inhibition.

Stromal mediated DNA damage promotes high grade serous ovarian cancer initiation

This study identifies high-risk mesenchymal stem cells (hrMSCs) that drive DNA damage and promote high-grade serous ovarian cancer initiation in fallopian tube epithelium.

Spatial landscape of malignant pleural and peritoneal mesothelioma tumor immune microenvironment

This study uses spatial analysis to examine immune cell distribution in mesothelioma tumors and its association with gene expression and patient outcomes.

Immunocompetent murine model of Ewing sarcoma reveals role for TGFβ inhibition to enhance immune infiltrates in Ewing tumors during radiation

The paper develops an immunocompetent mouse model of Ewing sarcoma to show that TGFβ inhibition enhances immune infiltration and reduces metastasis during radiation therapy.

All-trans retinoic acid induces durable tumor immunity in IDH-mutant gliomas by rescuing transcriptional repression of the CRBP1-retinoic acid axis

This study shows that all-trans retinoic acid (ATRA) improves immune response in IDH-mutant gliomas by restoring the RA pathway, leading to tumor regression in mouse models and a clinical trial for human patients.

BAMM-SC: A Bayesian mixture model for clustering droplet-based single cell transcriptomic data from population studies

BAMM-SC clusters droplet-based scRNA-seq data from multiple individuals by accounting for batch effects and heterogeneity, improving accuracy over existing methods.