Hanah Goetz

Double-edged role of resource competition in gene expression noise and control

This study investigates how resource competition affects gene expression noise and identifies strategies to control it using feedback controllers and orthogonal resources.

Winner-Takes-All Resource Competition Redirects Cascading Cell Fate Transitions

The paper demonstrates a 'winner-takes-all' resource competition in synthetic gene circuits, showing how it redirects cell fate transitions and proposes a division of labor strategy to mitigate its effects.

Topology-Dependent Interference of Circuit Function by Growth Feedback

This study shows growth feedback affects memory gene circuits differently based on network topology, with self-activation circuits losing memory faster than toggle switches.

A Plausible Accelerating Function of Intermediate States in Cancer Metastasis

The paper investigates how intermediate states in EMT affect cancer metastasis by using a hidden Markov model to show that more intermediate states accelerate the process.