Juan Ramon Melendez-Alvarez

Emergent Oscillation Induced by Nutrient-Modulating Growth Feedback

The paper reports oscillatory behavior in a self-activation gene circuit induced by nutrient-modulating growth feedback and validates it with a mathematical model.

Winner-Takes-All Resource Competition Redirects Cascading Cell Fate Transitions

The paper demonstrates a 'winner-takes-all' resource competition in synthetic gene circuits, showing how it redirects cell fate transitions and proposes a division of labor strategy to mitigate its effects.

Topology-Dependent Interference of Circuit Function by Growth Feedback

This study shows growth feedback affects memory gene circuits differently based on network topology, with self-activation circuits losing memory faster than toggle switches.

A Plausible Accelerating Function of Intermediate States in Cancer Metastasis

The paper investigates how intermediate states in EMT affect cancer metastasis by using a hidden Markov model to show that more intermediate states accelerate the process.