Author

Nicholas E. S. Tay

Princeton UniversityORCID 0000-0002-4063-8880Unclaimed ORCID profile · follow to get notified of new preprints

Biology Disciplines

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Signature Assays, Organisms & Methods

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Approach:experimental assay· 2 Research Focus:protein folding & dynamics· 1 Assay:protein sequence· 1 Assay:protein structure· 1

Frequent Co-Authors

Tom W. MuiriD· 2 shared Xuanjia YeiD· 2 shared Christian KofoediD· 1 shared Girum ErkaloiD· 1 shared Hengyuan LiuiD· 1 shared Jeremy A. OweniD· 1 shared Robert E. ThompsoniD· 1 shared Yi Hua· 1 shared

Activity by Year

2023-2025 · peak 1/yr

Co-Author Collaboration Network

8 top collaborators · 20 mutual co-author links

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2 shared papersBiochemistry

Tom W. MuirORCID

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2 papers

Recent·Most cited

Protein Editing using a Concerted Transposition Reaction

Yi Hua, Nicholas E. S. Tay, Xuanjia Ye, Jeremy A. Owen, Hengyuan Liu, Robert E. Thompson, Tom W. Muir

This paper introduces a method to replace internal protein regions in vitro using split inteins, enabling efficient protein semisynthesis under native folding conditions.

Science · Apr 4, 2025Peer-reviewedBiochemistry

Cell surface sculpting using logic-gated protein actuators

Christian Kofoed, Nicholas E. S. Tay, Xuanjia Ye, Girum Erkalo, Tom W. Muir

This paper introduces a protein actuator platform that performs Boolean logic operations on cell surfaces using proximity-gated trans-splicing, enabling selective recruitment of enzymatic and cytotoxic activities to specific cells.

bioRxiv · Dec 18, 2023 · PreprintSynthetic Biology