Tom W. Muir

This study identifies the active export of AgrD (1-32) thiolactone by AbcA and PmtCD transporters, enabling AIP production on the cell surface via MroQ protease.

This study identifies KMT2E as a reader of H3K4me3Q5ser, showing its role in regulating chromatin dynamics and neurodevelopmental gene expression in ODLURO syndrome.

This study identifies QR2 as a reader of H3Q5ser, showing its role in human neuron development through transcriptional and electrophysiological effects.

This study identifies Todstoff, a novel aversive cue in C. elegans that induces necrotaxis behaviors by signaling through ASH neurons and GPCR pathways.

The paper identifies SWIFT, a SWI/SNF subunit domain that mediates transcription factor interactions, showing its role in chromatin targeting and cancer cell proliferation.

This paper characterizes the split intein NrdJ-1, showing its rapid and promiscuous splicing properties for traceless protein modification in vitro and in cells.

This paper introduces a method to replace internal protein regions in vitro using split inteins, enabling efficient protein semisynthesis under native folding conditions.

The paper identifies dopaminylated proteins in the brain, including γCaMKII, and shows its role in synaptic-to-nuclear signaling and memory formation.

This paper introduces a protein actuator platform that performs Boolean logic operations on cell surfaces using proximity-gated trans-splicing, enabling selective recruitment of enzymatic and cytotoxic activities to specific cells.

A single enzyme, TGM2, bidirectionally controls H3 monoaminylation dynamics, which, in turn, facilitate neural rhythmicity.

This study shows that DOT1L regulates transcriptional initiation by facilitating TFIID recruitment and modulating H2B monoubiquitination, challenging its previously assumed role in transcriptional elongation.

The paper shows JASPer anchors JIL-1 to chromatin via H3K36me3 binding, forming a complex that regulates transcription and prevents heterochromatin formation in Drosophila.

This study identifies a novel DNA 6mA methyltransferase in ciliates and shows 6mA affects chromatin organization and gene expression.