Robert E. Thompson

Protein Editing using a Concerted Transposition Reaction

This paper introduces a method to replace internal protein regions in vitro using split inteins, enabling efficient protein semisynthesis under native folding conditions.

Hippocampal γCaMKII dopaminylation promotes synaptic-to-nuclear signaling and memory formation

The paper identifies dopaminylated proteins in the brain, including γCaMKII, and shows its role in synaptic-to-nuclear signaling and memory formation.

Histone monoaminylation dynamics are regulated by a single enzyme and promote neural rhythmicity

A single enzyme, TGM2, bidirectionally controls H3 monoaminylation dynamics, which, in turn, facilitate neural rhythmicity.

Reconstitution of eukaryotic chromosomes and manipulation of DNA N6-methyladenine alters chromatin and gene expression

This study identifies a novel DNA 6mA methyltransferase in ciliates and shows 6mA affects chromatin organization and gene expression.