Author

Sarah Butterfield

Royal Veterinary CollegeORCID 0000-0002-4064-0729Unclaimed ORCID profile · follow to get notified of new preprints

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Approach:biophysical modeling· 1 Research Focus:cell signaling & trafficking· 1 Research Focus:differential expression· 1 Research Focus:drug response / drug discovery· 1 Approach:experimental assay· 1 Organism:human· 1 Assay:proteomics· 1

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Patrick Alfryn LewisiD· 1 shared Susanne HerbstiD· 1 shared

Activity by Year

2025-2025 · peak 1/yr

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2 top collaborators · 1 mutual co-author link

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1 shared paperBiochemistry

Patrick Alfryn LewisORCID

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1 paper

Recent·Most cited

Loss-of-function coding variants in the Ras of Complex Proteins/GTPase domain of Leucine Rich Repeat Kinase 2

Sarah Butterfield, Susanne Herbst, Patrick Alfryn Lewis

The paper identifies three rare coding variants in LRRK2 that disrupt GTP binding and kinase activity, supporting their role in Parkinson's disease risk and drug target potential.

Protein Science · Jun 22, 2025Peer-reviewedBiochemistry