Susanne Herbst

This study investigates the functional consequences of catalytic activity loss in LRRK2, showing impaired proteostasis and altered interactome in guanosine nucleotide-depleted Lrrk2.

This study identifies GPNMB as a biomarker for lysosomal dysfunction and shows it is secreted via LRRK2-modulated lysosomal exocytosis in macrophages.

The paper investigates the role of glutamic acid at position 168 in TBK1 kinase activity, finding it acts as a constitutive activator.

The paper identifies three rare coding variants in LRRK2 that disrupt GTP binding and kinase activity, supporting their role in Parkinson's disease risk and drug target potential.