Hepatic γδ NKT cells modulate liver-resident CD8+ T cells to attenuated malaria parasite vaccines
Rebecca C. Blyn, Aditi V Kulkarni, Alexandra N. Donlan, Ashley Anne Krakauer, Gina Jones, Sydney M. Nemphos, Noah Stegman, Emily G Tanner, Nina Hertoghs, Katharine V. Schwedhelm, Stephen C. De Rosa, Ken Stuart, Cole G. Phalen, Lucas T. Graybuck, Peter J. Skene, , Nana K. Minkah
This study identifies hepatic γδ NKT cells as modulators of liver-resident CD8+ T cell responses in malaria vaccine efficacy, showing their role in protection through IFNγ production and tissue-homing properties.
bioRxiv · Aug 25, 2026 · PreprintImmunology