Peter J. Skene

This study shows that HIV-1 DNA/rAd5 vaccination leads to distinct clonal expansion and memory precursor states in Env- and Gag-specific CD8 T cells.

This study investigates the molecular effects of RVd therapy on T cells using TEA-seq, revealing how individual and sequential drug administration impacts T cell function and states.

This study identifies hepatic γδ NKT cells as modulators of liver-resident CD8+ T cell responses in malaria vaccine efficacy, showing their role in protection through IFNγ production and tissue-homing properties.

The paper identifies diverse human antibody-secreting cell subsets using multi-omic methods and shows their distinct functional and spatial characteristics.

This study shows how multiple myeloma and its treatment alter the bone marrow niche, impairing immune reconstitution and vaccine responses, with mRNA vaccines showing better efficacy than influenza vaccines.

The paper creates a cell-type-specific IFN response atlas to distinguish IFN-I and IFN-II activities in human immune cells across diseases.

This study uses multi-omic profiling to analyze immune cell dynamics in healthy adults over time, finding age-related transcriptional changes in T cells and impaired memory B cell responses in older adults.

REFLEX enables scalable, multiomic T cell profiling with TCR sequencing, identifying novel CMV-reactive clonotypes in over 1.4 million T cells.

This study identifies two distinct CD4+ T cell populations in inflamed lungs, showing that TCF1+ progenitor cells in tertiary lymphoid structures drive Th2 responses in allergic disease.

The paper identifies immune alterations preceding rheumatoid arthritis onset and provides tools for dataset exploration.

The paper identifies shared transcriptional and cell communication signatures in RA patients and at-risk individuals, showing how multiple pathogenic mechanisms contribute to disease initiation and progression.

CryoSCAPE enables scalable immune profiling using cryopreserved whole blood for multi-omic single cell and functional assays, demonstrating compatibility with high-throughput RNA sequencing and functional testing.

SPARROW integrates spatial transcriptomics and scRNA-seq to identify microenvironment zones and their influence on cell states and functions across tissues.

MOCHA improves scATAC-seq analysis by addressing technical and biological challenges, enabling better gene regulatory insights in human disease.

The paper introduces an improved CUT&RUN protocol that enables high-quality epigenomic profiling with low cell numbers and reduced experimental time.

The paper introduces CUT&RUN, a method for high-resolution mapping of DNA binding sites with lower sequencing depth and background compared to ChIP, and demonstrates its effectiveness in yeast and human nuclei.

The paper builds genome-scale transcriptional regulatory networks for mouse and human striatum, identifying SMAD3 as a key regulator in Huntington’s disease.