Cole G. Phalen

Hepatic γδ NKT cells modulate liver-resident CD8+ T cells to attenuated malaria parasite vaccines

This study identifies hepatic γδ NKT cells as modulators of liver-resident CD8+ T cell responses in malaria vaccine efficacy, showing their role in protection through IFNγ production and tissue-homing properties.

Multi-omic profiling of human antibody-secreting cells reveals diverse subsets sustain durable humoral immunity

The paper identifies diverse human antibody-secreting cell subsets using multi-omic methods and shows their distinct functional and spatial characteristics.

Myeloma and therapy reshape the bone marrow niche to durably constrain immune reconstitution and vaccine responsiveness

This study shows how multiple myeloma and its treatment alter the bone marrow niche, impairing immune reconstitution and vaccine responses, with mRNA vaccines showing better efficacy than influenza vaccines.

Longitudinal Multi-omic Immune Profiling Reveals Age-Related Immune Cell Dynamics in Healthy Adults

This study uses multi-omic profiling to analyze immune cell dynamics in healthy adults over time, finding age-related transcriptional changes in T cells and impaired memory B cell responses in older adults.

Systemic inflammation and lymphocyte activation precede rheumatoid arthritis

The paper identifies immune alterations preceding rheumatoid arthritis onset and provides tools for dataset exploration.

CryoSCAPE: Scalable Immune Profiling Using Cryopreserved Whole Blood for Multi-omic Single Cell and Functional Assays

CryoSCAPE enables scalable immune profiling using cryopreserved whole blood for multi-omic single cell and functional assays, demonstrating compatibility with high-throughput RNA sequencing and functional testing.