Kevin R. Nash

A mouse model of early sporadic tau pathology induces neurogenic plasticity in the hippocampus

This study uses a mouse model to show that early tau pathology in the entorhinal cortex induces morphological changes and neurogenic plasticity in the hippocampus without affecting synaptic strength.

Probing tau citrullination in Alzheimer's disease brains and mouse models of tauopathy

The paper identifies citrullination of tau as a novel posttranslational modification in Alzheimer's disease and tauopathy models, showing its association with disease progression.

Nutrient Sensing Receptor GPRC6A Regulates mTORC1 Signaling and Tau Biology

This study identifies GPRC6A as a key regulator of mTORC1 signaling and tau pathology in tauopathies, showing that targeting GPRC6A could reduce tau accumulation and related neurodegeneration.

A preclinical pig model of Angelman syndrome mirrors the early developmental trajectory of the human condition

This paper describes a pig model of Angelman syndrome that mirrors early developmental symptoms observed in humans.

Citrullination of TDP-43 is a key post-translation modification associated with structural and functional changes and progressive pathology in TDP-43 mouse models and human proteinopathies

This study identifies citrullination as a novel irreversible post-translational modification of TDP-43 linked to structural changes, aggregation, and pathology in TDP-43 proteinopathies.

Development of an ASO therapy for Angelman syndrome by targeting an evolutionarily conserved region at the start of the UBE3A-AS transcript

This paper describes the development of an antisense oligonucleotide (ASO) therapy targeting the UBE3A-AS transcript to reactivate paternal UBE3A expression in Angelman syndrome models.