Samuel Neuenschwander

Prevalence of Oxalotrophy in the Human Microbiome

The paper identifies oxalotrophy as a rare metabolic trait in the human microbiome, primarily confined to the gut, and finds evidence of horizontal gene transfer for the trait.

Microbiome variations in osteoarthritis reflect aging and metabolic factors, not the disease

This study analyzes microbiome data from multiple OA cohorts and finds no significant differences between OA patients and controls, attributing microbiome changes to age and BMI instead of OA.

Fighting Aspergillus infection using biocontrol bacteria: A proof-of-concept of environmental interference in a translational setting

The paper demonstrates biocontrol using oxalotrophic bacteria to combat Aspergillus niger in a mouse infection model by interfering with oxalic acid production.

Benchmarking metagenomics classifiers on ancient viral DNA: a simulation study

This study benchmarks metagenomics classifiers on simulated ancient viral DNA to identify the most effective tool for detecting human DNA viruses in degraded samples.

Indigenous peoples in eastern Brazil: insights from 19th century genomes and metagenomes

The paper sequences 24 ancient Brazilian genomes, including 22 Botocudos, revealing Indigenous American ancestry without external gene flow and low heterozygosity, and identifies ancient pathogen lineages.

Assessing natural selection during range expansions: Insights from a spatially explicit ABC study

This study uses spatially explicit ABC simulations to assess natural selection during range expansions, finding that isolation-by-distance statistics reliably estimate selection strength despite genetic and demographic noise.

Complex genetic patterns in human arise from a simple range-expansion model over continental landmasses

The paper uses simulations and Bayesian methods to show a simple range-expansion model explains much of human genetic diversity.