Sutharsan Govindarajan

A phiKMV ligase-dependent DNA repair mechanism that mitigates DNA-targeting nucleases

The paper identifies a DNA repair mechanism in phages that allows them to resist CRISPR-Cas and R-M systems by repairing nuclease-induced breaks via a ligase-dependent process.

Periplasmic proteostasis enables bacterial survival during MreB cytoskeletal disruption

This study identifies genes and mechanisms involved in bacterial survival after MreB disruption, showing that DegP protease is critical for tolerance to the antibiotic A22.

KilR of E. coli Rac prophage is a dual morphogenetic inhibitor of bacterial cell shape

This study identifies KilR as a dual morphogenetic inhibitor that targets both FtsZ-mediated cell division and MreB-mediated cell elongation, enhancing bacterial survival during oxidative stress.

Probing the Molecular Interactions of A22 with Prokaryotic Actin MreB and Eukaryotic Actin: A Computational and Experimental Study

This study investigates A22's interactions with prokaryotic MreB and eukaryotic actin using computational and experimental methods, revealing strong binding and toxicity to eukaryotic cells.