Author

Lawrence Tychsen

ORCID 0000-0002-4083-1576Unclaimed ORCID profile · follow to get notified of new preprints

Biology Disciplines

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Genetic & Genomic Medicine· 1

Signature Assays, Organisms & Methods

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Research Focus:drug response / drug discovery· 1 Approach:experimental assay· 1 Organism:human· 1

Frequent Co-Authors

Ashley N. Simpson· 1 shared Bess Adkins MarshalliD· 1 shared Chinyere Onwumere· 1 shared CRIS M. BROWN· 1 shared Damien AbreuiD· 1 shared Fumihiko UranoiD· 1 shared Gregory P. Van StaverniD· 1 shared Hongjie GuiD· 1 shared

Activity by Year

2021-2021 · peak 1/yr

Co-Author Collaboration Network

10 top collaborators · 45 mutual co-author links

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1 shared paperGenetic & Genomic Medicine

Ashley N. Simpson

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1 paper

Recent·Most cited

A Phase 1b/2a Clinical Trial of Dantrolene Sodium in Patients with Wolfram Syndrome

Damien Abreu, Stephen Stone, Toni S. Pearson, Robert C. Bucelli, Ashley N. Simpson, Stacy Hurst, CRIS M. BROWN, Kelly Kries, Chinyere Onwumere, Hongjie Gu, James Hoekel, Lawrence Tychsen, Gregory P. Van Stavern, Neil H. White, Bess Adkins Marshall, , Fumihiko Urano

This paper reports a phase 1b/2a clinical trial of dantrolene sodium in Wolfram syndrome patients, showing it is well tolerated and showing some potential efficacy in beta-cell function and visual acuity.

JCI Insight · Jun 29, 2021Peer-reviewedGenetic & Genomic Medicine