Author

CRIS M. BROWN

Washington University in St. Louis

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Genetic & Genomic Medicine· 3 Genetics· 1

Signature Assays, Organisms & Methods

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Organism:human· 4 Research Focus:drug response / drug discovery· 2 Approach:experimental assay· 2 Approach:statistical model· 2 Research Focus:cell type annotation· 1 Research Focus:differential expression· 1

Frequent Co-Authors

Fumihiko UranoiD· 4 shared Stacy Hurst· 3 shared Bess Adkins MarshalliD· 2 shared Kelly KriesiD· 2 shared Tamara G. HersheyiD· 2 shared Abby F. Tang· 1 shared Anton M. SimeonoviD· 1 shared Ashley N. Simpson· 1 shared

Activity by Year

2021-2026 · peak 2/yr

Co-Author Collaboration Network

10 top collaborators · 28 mutual co-author links

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4 shared papersGenetic & Genomic Medicine

Fumihiko UranoORCID

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4 papers

Recent·Most cited

Natural history of patients with autosomal dominant WFS1 pathogenic variants associated with sensorineural hearing loss and optic atrophy

Jessica P. Roberts, Abby F. Tang, Daniela Soto Hernández, B. Carman, Liam Oiknine, CRIS M. BROWN, Stacy Hurst, Yunshuo Tang, Fumihiko Urano

This study analyzes clinical data from 11 patients with autosomal dominant WFS1 variants to describe the natural history of optic atrophy and sensorineural hearing loss, identifying a novel variant and providing insights into disease progression.

Orphanet Journal of Rare Diseases · Apr 18, 2026Peer-reviewedGenetic & Genomic Medicine

Genotype and Clinical Characteristics of Patients with Wolfram Syndrome and WFS1-related Disorders

Evan M. Lee, Megha Verma, Nila Palaniappan, Emiko M. Pope, Sammie Lee, Lindsey Blacher, Pooja Neerumalla, William An, Toko Campbell, CRIS M. BROWN, Stacy Hurst, Bess Adkins Marshall, Tamara G. Hershey, Virginia Nunes, Miguel López de Heredia, Fumihiko Urano

This study investigates the genotype-phenotype relationship in Wolfram syndrome, finding that specific WFS1 gene variants correlate with earlier onset and more severe disease manifestations.

Frontiers in Genetics · Jun 21, 2023Peer-reviewedGenetic & Genomic Medicine

Genotype-phenotype correlation analysis and therapeutic development using a patient stem cell-derived disease model of Wolfram syndrome

Rie Asada Kitamura, Kristina G. Maxwell, Wenjuan Ye, Kelly Kries, CRIS M. BROWN, Punn Augsornworawat, Yoel Hirsch, Martin M. Johansson, Tzvi Weiden, Joseph Ekstein, Joshua N. Cohen, Justin B. Klee, Kent L. Leslie, Anton M. Simeonov, Mark J. Henderson, , Fumihiko Urano

This study uses a patient-derived stem cell model to show that a specific WFS1 variant causes mild Wolfram syndrome, which can be treated with chemical chaperones.

bioRxiv · Nov 7, 2021 · PreprintGenetics

A Phase 1b/2a Clinical Trial of Dantrolene Sodium in Patients with Wolfram Syndrome

Damien Abreu, Stephen Stone, Toni S. Pearson, Robert C. Bucelli, Ashley N. Simpson, Stacy Hurst, CRIS M. BROWN, Kelly Kries, Chinyere Onwumere, Hongjie Gu, James Hoekel, Lawrence Tychsen, Gregory P. Van Stavern, Neil H. White, Bess Adkins Marshall, , Fumihiko Urano

This paper reports a phase 1b/2a clinical trial of dantrolene sodium in Wolfram syndrome patients, showing it is well tolerated and showing some potential efficacy in beta-cell function and visual acuity.

JCI Insight · Jun 29, 2021Peer-reviewedGenetic & Genomic Medicine