Author

Chinyere Onwumere

Washington University in St. Louis

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Genetic & Genomic Medicine· 1 Molecular Biology· 1

Signature Assays, Organisms & Methods

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Approach:experimental assay· 2 Research Focus:drug response / drug discovery· 1 Organism:human· 1 Organism:mouse· 1

Frequent Co-Authors

Fumihiko UranoiD· 2 shared Ashley N. Simpson· 1 shared Bess Adkins MarshalliD· 1 shared CRIS M. BROWN· 1 shared Damien AbreuiD· 1 shared Gregory P. Van StaverniD· 1 shared Hongjie GuiD· 1 shared James HoekeliD· 1 shared

Activity by Year

2021-2022 · peak 1/yr

Co-Author Collaboration Network

10 top collaborators · 45 mutual co-author links

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2 shared papersMolecular Biology

Fumihiko UranoORCID

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2 papers

Recent·Most cited

Anti-inflammatory effects of WFS1 in pancreatic beta-cells

Shuntaro Morikawa, Lindsey Blacher, Chinyere Onwumere, Fumihiko Urano

This study shows that WFS1 deficiency in pancreatic beta-cells increases inflammation, leading to ER stress and cell death, and identifies potential therapeutic targets for Wolfram syndrome.

bioRxiv · Feb 9, 2022 · PreprintMolecular Biology

A Phase 1b/2a Clinical Trial of Dantrolene Sodium in Patients with Wolfram Syndrome

Damien Abreu, Stephen Stone, Toni S. Pearson, Robert C. Bucelli, Ashley N. Simpson, Stacy Hurst, CRIS M. BROWN, Kelly Kries, Chinyere Onwumere, Hongjie Gu, James Hoekel, Lawrence Tychsen, Gregory P. Van Stavern, Neil H. White, Bess Adkins Marshall, , Fumihiko Urano

This paper reports a phase 1b/2a clinical trial of dantrolene sodium in Wolfram syndrome patients, showing it is well tolerated and showing some potential efficacy in beta-cell function and visual acuity.

JCI Insight · Jun 29, 2021Peer-reviewedGenetic & Genomic Medicine