Hepatic cytochrome P450 endoplasmic reticulum-associated degradation (ERAD): Topological determinants and cellular partnerships that dictate the preferential P450 proteolytic sorting into macroautophagy rather than UPS.
Hong Xiao, Liang He, Yi Liu, Jinyu Luo, Xiaokun Shu, Maria Almira Correia
This study identifies how the topology of ER-microdomains and interactions with erlin-1 determine the proteolytic fate of P450s via ERAD or ERLAD.
bioRxiv · Sep 25, 2025 · PreprintCell Biology