ISOTOPE: ISOform-guided prediction of epiTOPEs in cancer
Juan L. Trincado, Marina Reixachs‐Solé, Judith Pérez‐Granado, Tim Fugmann, Ferrán Sanz, Jun Yokota, Eduardo Eyras
ISOTOPE identifies tumor-specific splicing-derived epitopes using RNA sequencing and mass spectrometry, showing splicing neoepitopes have higher MHC-I binding affinity in immune responders.
PLoS Computational Biology · Sep 16, 2021Peer-reviewedBioinformatics