Author

Quanshun Li

Jilin UniversityORCID 0000-0002-4115-7552Unclaimed ORCID profile · follow to get notified of new preprints

Biology Disciplines

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Signature Assays, Organisms & Methods

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Approach:experimental assay· 3 Assay:DNA methylation· 2 Assay:whole-genome sequencing· 2 Approach:Bayesian inference· 1 Research Focus:database / resource· 1 Approach:deep learning· 1 Organism:E. coli· 1 Approach:machine learning (classical)· 1

Frequent Co-Authors

Di LiuiD· 2 shared Lijia JiaiD· 2 shared Bo DuaniD· 1 shared Dongbo BuiD· 1 shared Enyang Yu· 1 shared Fengqian CheniD· 1 shared Haizhou Liu· 1 shared Haobo HaniD· 1 shared

Activity by Year

2025-2026 · peak 2/yr

Co-Author Collaboration Network

10 top collaborators · 20 mutual co-author links

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2 shared papersSynthetic Biology

Di LiuORCID

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Author profile →

4 papers

Recent·Most cited

Evolution-inspired multi-objective Bayesian optimization for protein engineering

Kai Wen, Sirui Wang, Yixin Sun, Shiwen Li, Mengsong Wang, Haoyang Liu, Quanshun Li, Jingxuan Zhu

This paper introduces EvoMOBO, a multi-objective Bayesian optimization framework for protein engineering, showing improved performance in enzyme tasks compared to wild-type variants.

bioRxiv · Aug 6, 2026 · PreprintBioengineering

DNA Data Storage Architecture via Ligation of Dynamic DNA Bytes

Lijia Jia, Yue Shi, Jing Yang, Shangzhe Li, Wenjing Yang, Wei Li, Mancang Zhang, Quanshun Li, Yifei Zhang, Xiaolin Wang, Lin Li, Bo Duan, Dongbo Bu, Fengqian Chen, Haizhou Liu, , Di Liu

This paper introduces a modular DNA storage system using dynamic DNA bytes that enables reconfigurable, rewritable data storage with CRUD operations and error correction.

Small Methods · Mar 31, 2026Peer-reviewedSynthetic Biology

Engineering chimeric DNA polymerases for DNA movable type storage

Xutong Liu, Qixuan Zhao, Enyang Yu, Lijia Jia, Yue Xi Shi, Di Liu, Haobo Han, Quanshun Li

This paper engineers chimeric DNA polymerases to improve DNA storage by enabling flexible data rewriting and reducing synthesis demands.

bioRxiv · Dec 19, 2025 · PreprintSynthetic Biology

Computer-assisted dissection of the DNA mismatch recognition mechanism of the MutS protein

Wenyang Jiang, Yiyang Ding, Yuxuan Li, Haojie Sun, Xiao Huan Liang, Quanshun Li

The paper explains how TaqMutS recognizes DNA mismatches through a push-pull mechanism involving specific residues and electrostatic interactions.

bioRxiv · Dec 16, 2025 · PreprintSynthetic Biology