bioRxivSynthetic BiologyPreprint
Computer-assisted dissection of the DNA mismatch recognition mechanism of the MutS protein
Wenyang JiangiD, Yiyang Ding, Yuxuan LiiD, Haojie SuniD, Xiao Huan LiangiD, Quanshun LiiD
Abstract
By sensing local conformational strains in DNA, TaqMutS utilizes a push-pull mechanism via the synergy of residues S57 and D472 to modulate {pi}-stacking interactions between the key recognition residue F39 and DNA, thereby achieving specific mismatch-site recognition. Meanwhile, residues K61 and R473 fine-tune non-specific binding of TaqMutS through electrostatic synergy.
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