Skeletal myotubes expressing ALS mutant SOD1 induce pathogenic changes, impair mitochondrial axonal transport, and trigger motoneuron death.
Pablo Martínez, Mónica Silva, Sebastián Abarzúa, María Florencia Tevy, Enrique Jaimovich, Martha Constantine‐Paton, Fernando J. Bustos, Brigitte van Zundert
This study shows that skeletal myotubes with ALS-linked mutant SOD1 release factors that cause motoneuron axonopathy and death.
Molecular Medicine · Oct 25, 2024Peer-reviewedNeuroscience