Enrique Jaimovich

Chemogenetic Mitochondrial H2O2 Generation Triggers Dose-Dependent Skeletal Muscle Wasting Signatures

This study uses chemogenetics to induce mitochondrial H2O2 in skeletal muscle and shows it causes dose-dependent atrophy without structural damage.

Skeletal myotubes expressing ALS mutant SOD1 induce pathogenic changes, impair mitochondrial axonal transport, and trigger motoneuron death.

This study shows that skeletal myotubes with ALS-linked mutant SOD1 release factors that cause motoneuron axonopathy and death.