Author

Fernando J. Bustos

Universidad Andrés BelloORCID 0000-0002-0487-7032Unclaimed ORCID profile · follow to get notified of new preprints

Biology Disciplines

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Signature Assays, Organisms & Methods

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Approach:experimental assay· 7 Organism:mouse· 6 Research Focus:cell type annotation· 1 Research Focus:cell-cell communication· 1 Research Focus:differential expression· 1 Organism:human· 1

Frequent Co-Authors

Martha Constantine‐Paton· 4 shared Bastián BraueriD· 2 shared Constanza Ahumada-Marchant· 2 shared Gloria ArriagadaiD· 2 shared Henny Haensgen· 2 shared Jian-Ping Zhao· 2 shared Nicolás Merino-Véliz· 2 shared Swarna Pandian· 2 shared

Activity by Year

2020-2026 · peak 3/yr

Co-Author Collaboration Network

10 top collaborators · 23 mutual co-author links

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4 shared papersNeuroscience

Martha Constantine‐Paton

Mutual co-authors in cluster

Author profile →

7 papers

Recent·Most cited

Deletion of the MALAT1 RNA 3' end Promotes Transcript Decay and Inhibits Proliferation in Gastric and Breast Cancer Cells

Aramis Cortes-Arias, Valeria Valdes, Marcelo Muñoz-González, Diego Leiva, Andrew Acevedo, Michelle Tobar-Lara, Nicole Farfán, Lilly Oni, Eduardo Quiñones‐Medina, Verónica A. Burzio, Adriana Rojas, Roberto Munita, Srinivas Somarowthu, Fernando J. Bustos, Rodrigo Aguilar

This study shows that deleting the 3' end of MALAT1 RNA reduces its stability and inhibits cancer cell proliferation in gastric and breast cancer models.

International Journal of Biological Macromolecules · Aug 25, 2026Peer-reviewedMolecular Biology

Skeletal myotubes expressing ALS mutant SOD1 induce pathogenic changes, impair mitochondrial axonal transport, and trigger motoneuron death.

Pablo Martínez, Mónica Silva, Sebastián Abarzúa, María Florencia Tevy, Enrique Jaimovich, Martha Constantine‐Paton, Fernando J. Bustos, Brigitte van Zundert

This study shows that skeletal myotubes with ALS-linked mutant SOD1 release factors that cause motoneuron axonopathy and death.

Molecular Medicine · Oct 25, 2024Peer-reviewedNeuroscience

RSPO/LGR signaling mediates astrocyte-induced proliferation of adult hippocampal neural stem cells

Daniela Valenzuela-Bezanilla, Muriel D. Mardones, Maximiliano Galassi, Sebastián B. Arredondo, Sebastian H Santibanez, Stephanie Gutierrez-Jimenez, Nicolás Merino-Véliz, Fernando J. Bustos, Lorena Varela‐Nallar

This study identifies RSPO/LGR signaling as a mechanism by which astrocytes regulate proliferation of adult hippocampal neural stem cells through Wnt signaling.

Stem Cells · Oct 17, 2024Peer-reviewedNeuroscience

KMT2C knockout generates ASD-like behaviors in mice.

Bastián Brauer, Nicolás Merino-Véliz, Constanza Ahumada-Marchant, Gloria Arriagada, Fernando J. Bustos

This study shows that KMT2C knockout in mice leads to ASD-like behaviors including repetitive actions, social deficits, and intellectual disability.

Frontiers in Cell and Developmental Biology · Jul 19, 2023Peer-reviewedMolecular Biology

Deletion of VPS50 protein in mice brain impairs synaptic function and behavior

Constanza Ahumada-Marchant, Carlos Ancatén-González, Henny Haensgen, Felipe Arancibia, Bastián Brauer, Rita Droste, Howard Robert Horvitz, Martha Constantine‐Paton, Gloria Arriagada, Andrés E. Chávez, Fernando J. Bustos

This study shows that deleting VPS50 in mice brains impairs synaptic function and behavior by disrupting V-ATPase pump localization and vesicle acidification.

bioRxiv · Jul 4, 2023 · PreprintNeuroscience

Removal of a genomic duplication by double-nicking CRISPR restores synaptic transmission and behavior in the MyosinVA mutant mouse Flailer.

Fernando J. Bustos, Swarna Pandian, Henny Haensgen, Jian-Ping Zhao, Haley Strouf, Matthias Heidenreich, Lukasz J. Swiech, Benjamin E. Deverman, Viviana Gradinaru, Feng Zhang, Martha Constantine‐Paton

This study removes a genomic duplication in a mouse model using DN-CRISPRs, improving synaptic transmission and behavior.

bioRxiv · Apr 28, 2023 · PreprintNeuroscience

Myosin Va Brain-Specific Mutation Alters Mouse Behavior and Disrupts Hippocampal Synapses

Swarna Pandian, Jian-Ping Zhao, Yasunobu Murata, Fernando J. Bustos, Cansu Tunca, Ramiro D. Almeida, Martha Constantine‐Paton

This paper describes a Myosin Va mutation in mice that causes synaptic transport defects and behavioral abnormalities resembling anxiety/autism spectrum disorders.

eNeuro · Nov 1, 2020Peer-reviewedNeuroscience