High-Throughput Measurement of Metastable DNA Secondary Structures Using Multiplexed Low-Yield Bisulfite Sequencing (MLB-seq)
Jiaming Li, Jin H. Bae, Boyan Yordanov, Michael Wang, Andrew Phillips, David Yu Zhang
This paper introduces MLB-seq, a method to profile DNA secondary structures using bisulfite sequencing, and finds that 84% of studied human genome subsequences adopt multiple structures.
bioRxiv · May 21, 2021 · PreprintMolecular Biology