Katrin Böttcher

The paper shows that periweaning diet activates an IFNγ-mediated circuit in cDC1 that promotes effector memory CD8 T cell homeostasis through immunogenic maturation.

This study shows that high-fat diets promote GEAC by altering the microbiota-Bile Acid axis and inhibiting FXR, with FXR agonists like OCA slowing disease progression.

This study identifies KRAS mutation as a driver of invasive gastro-esophageal adenocarcinoma in a mouse model, showing its synergistic role with Tp53 or Rb1 loss and potential as a therapeutic target.