Cancer BiologyCellular and Molecular Gastroenterology and HepatologyPeer-reviewed
Microbiota metabolized Bile Acids accelerate Gastroesophageal Adenocarcinoma via FXR inhibition
Theresa Baumeister, Andrea Proaño-Vasco, Amira Metwaly…·Michael Quante
This study shows that high-fat diets promote GEAC by altering the microbiota-Bile Acid axis and inhibiting FXR, with FXR agonists like OCA slowing disease progression.
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