Author

Joshua A. Bittker

Broad InstituteORCID 0000-0002-4166-0828Unclaimed ORCID profile · follow to get notified of new preprints

Biology Disciplines

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Signature Assays, Organisms & Methods

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Assay:bulk RNA-seq· 2 Research Focus:differential expression· 2 Research Focus:gene regulatory network inference· 2 Research Focus:drug response / drug discovery· 1 Organism:human· 1 Approach:machine learning (classical)· 1 Approach:statistical model· 1 Research Focus:variant effect prediction· 1

Frequent Co-Authors

Aravind SubramanianiD· 2 shared Xiaodong LüiD· 2 shared Alice H. BergeriD· 1 shared Alykhan F. Shamji· 1 shared Amy Li· 1 shared Andrew A. TubelliiD· 1 shared Angela Norie BrooksiD· 1 shared Anita VrciciD· 1 shared

Activity by Year

2017-2019 · peak 1/yr

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10 top collaborators · 38 mutual co-author links

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2 shared papersBioinformatics

Aravind SubramanianORCID

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2 papers

Recent·Most cited

BioinformaticsEnvironmental Health PerspectivesPeer-reviewedApr 1, 2019

The Carcinogenome Project: In-vitro Gene Expression Profiling of Chemical Perturbations to Predict Long-Term Carcinogenicity

Amy Li, Xiaodong Lü, Ted E. Natoli…·Stefano Monti

The paper develops an in-vitro gene expression screening method to predict chemical carcinogenicity and genotoxicity using HepG2 cells and machine learning models.

28 citations

humanbulk RNA-seq

𝕏 PostBluesky

GenomicsCellPeer-reviewedNov 1, 2017

A Next Generation Connectivity Map: L1000 Platform And The First 1,000,000 Profiles

Aravind Subramanian, Rajiv Narayan, Steven M. Corsello…·Todd R. Golub

The paper introduces the L1000 platform, a high-throughput gene expression profiling method, and reports 1.3 million perturbational profiles expanding the Connectivity Map for drug mechanism discovery and functional annotation.

3,517 citationstop 1%

bulk RNA-seqstatistical model

𝕏 PostBluesky