Author

Anita Vrcic

Broad InstituteORCID 0000-0002-2941-5459Unclaimed ORCID profile · follow to get notified of new preprints

Biology Disciplines

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Signature Assays, Organisms & Methods

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Research Focus:benchmarking· 1 Assay:bulk RNA-seq· 1 Research Focus:differential expression· 1 Research Focus:drug response / drug discovery· 1 Approach:experimental assay· 1 Research Focus:gene regulatory network inference· 1 Assay:imaging· 1 Approach:statistical model· 1

Frequent Co-Authors

Adam P. SkepneriD· 1 shared Alice H. BergeriD· 1 shared Alykhan F. Shamji· 1 shared Amy B. GoodaleiD· 1 shared Andrew A. TubelliiD· 1 shared Angela Norie BrooksiD· 1 shared Anne Elizabeth CarpenteriD· 1 shared Aravind SubramanianiD· 1 shared

Activity by Year

2017-2023 · peak 1/yr

Co-Author Collaboration Network

10 top collaborators · 24 mutual co-author links

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1 shared paperBioinformatics

Adam P. SkepnerORCID

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2 papers

Recent·Most cited

Optimizing the Cell Painting assay for image-based profiling

Beth A. Cimini, Srinivas Niranj Chandrasekaran, Maria Kost‐Alimova, Lisa Miller, Amy B. Goodale, Briana Fritchman, Patrick J. Byrne, Sakshi Garg, Nasim Jamali, David J. Logan, John B. Concannon, Charles-Hugues Lardeau, Elizabeth Mouchet, Shantanu Singh, Hamdah Shafqat Abbasi, , Anne Elizabeth Carpenter

The paper updates the Cell Painting assay protocol to improve morphological profiling, finding that simplified steps and reduced stain concentrations maintain robust outputs.

Nature Protocols · Jun 21, 2023Peer-reviewedBioinformatics

A Next Generation Connectivity Map: L1000 Platform And The First 1,000,000 Profiles

Aravind Subramanian, Rajiv Narayan, Steven M. Corsello, David D. Peck, Ted Natoli, Xiaodong Lü, Joshua Gould, John F. Davis, Andrew A. Tubelli, Jacob K. Asiedu, David L. Lahr, Jodi Hirschman, Zihan Liu, Melanie K. Donahue, Bina Julian, , Todd R. Golub

The paper introduces the L1000 platform, a high-throughput gene expression profiling method, and reports 1.3 million perturbational profiles expanding the Connectivity Map for drug mechanism discovery and functional annotation.

Cell · Nov 1, 2017Peer-reviewedGenomics