Andrew A. Tubelli

Sound-Driven Motion of Human Cochlear Structures Depends on Organ of Corti Integrity

This study uses OCT to show that the anatomical integrity of the organ of Corti affects cochlear structural motion in human cadaveric specimens.

A nonlinear time-domain finite-element model of the human middle ear subjected to intense sound waves

This study develops a nonlinear finite-element model of the human middle ear to simulate its response to intense sound waves and identifies nonlinear behaviors under high-frequency and high-intensity conditions.

Computational model of the human cochlea with motion of the layered osseous spiral lamina

The paper develops a finite element model of the human cochlea incorporating the layered osseous spiral lamina, calibrated with experimental motion data, showing similar motion results within 5 dB but with high-frequency discrepancies.

A Library of Phosphoproteomic and Chromatin Signatures for Characterizing Cellular Responses to Drug Perturbations

The paper creates a proteomic resource profiling 90 drugs in six cell lines, revealing cell-specific responses and enabling integration with transcriptional data to identify therapeutic opportunities.

A Next Generation Connectivity Map: L1000 Platform And The First 1,000,000 Profiles

The paper introduces the L1000 platform, a high-throughput gene expression profiling method, and reports 1.3 million perturbational profiles expanding the Connectivity Map for drug mechanism discovery and functional annotation.