Steven M. Corsello

Ratiometric transcriptional activation by protein degradation

This paper introduces ratiometric transcriptional activation to detect protein abundance changes by converting protein degradation into gene expression outputs in live cells.

Mutational scanning reveals substrate-assisted autoregulation of the WNT destruction complex

The paper systematically maps the sequence-function landscape of the WNT destruction complex using mutational scanning, identifying novel mutations and revealing substrate-assisted autoregulation mechanisms.

A clinical-stage oncology compound selectively targets drug-resistant cancers

This study reveals that PAC-1, a clinical-stage oncology compound, targets drug-resistant cancers by disrupting iron homeostasis and exploiting MDR1 expression to induce iron depletion.

Development of potent and selective CK1α Molecular Glue Degraders

This study develops potent and selective CK1α molecular glue degraders through scaffold hopping and structure-activity relationship analysis of a glutarimide-based library.

Virtual screening for small molecule pathway regulators by image profile matching

The paper identifies small molecule regulators of biological pathways by matching compound effects to known pathway phenotypes in public cell image data.

A Next Generation Connectivity Map: L1000 Platform And The First 1,000,000 Profiles

The paper introduces the L1000 platform, a high-throughput gene expression profiling method, and reports 1.3 million perturbational profiles expanding the Connectivity Map for drug mechanism discovery and functional annotation.