A candidate causal variant underlying both enhanced cognitive performance and increased risk of bipolar disorder
Susan Q. Shen, Jeong Sook Kim‐Han, Lin Cheng, Duo Xu, Ömer Gökçümen, Andrew E. O. Hughes, Connie A. Myers, Joseph C. Corbo
The paper identifies a candidate causal variant, rs77910749, that links enhanced cognitive performance with increased bipolar disorder risk through its effect on POU3F2 expression and amygdala function.
bioRxiv · Oct 28, 2021 · PreprintGenetics