Daniel Wells

Preventing premature deaths through polygenic risk scores

This study evaluates how polygenic risk scores can optimize screening programs to reduce premature deaths by tailoring screening ages based on genetic risk.

UK Biobank release and systematic evaluation of optimised polygenic risk scores for 53 diseases and quantitative traits

The paper releases and evaluates polygenic risk scores for 53 diseases and traits in the UK Biobank and shows they outperform existing scores.

ZCWPW1 is recruited to recombination hotspots by PRDM9, and is essential for meiotic double strand break repair

The paper identifies ZCWPW1 as a protein recruited by PRDM9 to recombination hotspots and shows it is essential for meiotic double strand break repair and fertility in mice.

Unified single-cell analysis of testis gene regulation and pathology in 5 mouse strains

The paper develops a framework to analyze single-cell transcriptomes from mouse testes, identifying gene regulatory programs and pathological processes in mutant strains.

Genome And Epigenome Engineering CRISPR Toolkit For Probing In Vivo cis-Regulatory Interactions In The Chicken Embryo

The paper develops a CRISPR-based toolkit for genome and epigenome engineering in chicken embryos to study gene regulatory interactions during neural crest development.