Author

Michel‐Edwar Mickael

Institute of Genetics and Animal Biotechnology of the Polish Academy of SciencesORCID 0000-0002-4186-4900Unclaimed ORCID profile · follow to get notified of new preprints

Biology Disciplines

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Bioinformatics· 3 Neuroscience· 2

Signature Assays, Organisms & Methods

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Assay:bulk RNA-seq· 2 Approach:deep learning· 2 Research Focus:differential expression· 2 Research Focus:drug response / drug discovery· 2 Approach:statistical model· 2 Organism:human· 1 Approach:machine learning (classical)· 1 Organism:mouse· 1

Frequent Co-Authors

Mariusz SacharczukiD· 2 shared Norwin KubickiD· 2 shared Pavel Klimovich· 2 shared Agnieszka KowalczykiD· 1 shared Alexandra Mickael· 1 shared Antonio CuadradoiD· 1 shared Ashish RajputiD· 1 shared Björn Hammesfahr· 1 shared

Activity by Year

2017-2022 · peak 1/yr

Co-Author Collaboration Network

10 top collaborators · 10 mutual co-author links

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2 shared papersBioinformatics

Mariusz SacharczukORCID

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Author profile →

5 papers

Recent·Most cited

Adera: A drug repurposing workflow for neuro-immunological investigations using neural networks.

Marzena Łazarczyk, Kamila Duda, Michel‐Edwar Mickael, Agnieszka Kowalczyk, Mariusz Sacharczuk

Adera is a deep learning model for drug repurposing in neuro-immunological diseases, achieving high accuracy in predicting drug targets.

bioRxiv · Jul 14, 2022 · PreprintBioinformatics

Predicting epitopes Based on TCR sequence using an embedding deep neural network artificial intelligence approach

Norwin Kubick, Pavel Klimovich, Mariusz Sacharczuk, Michel‐Edwar Mickael

The paper develops a deep neural network to predict epitopes from TCR beta-chain CDR3 sequences, achieving 98% accuracy using VDJdb and McPAS-TCR datasets.

bioRxiv · Aug 11, 2021 · PreprintBioinformatics

Asip (Agouti-signaling protein) aggression gene regulate auditory processing genes in mice

Alexandra Mickael, Pavel Klimovich, Patrick Henckel, Norwin Kubick, Michel‐Edwar Mickael

The paper investigates the role of ASIP in aggression and auditory processing in mice, finding upregulated auditory genes in ASIP knockout models and a correlation between lockdown-induced aggression and hearing changes.

bioRxiv · Jun 10, 2020 · PreprintNeuroscience

NRF2 drug repurposing using a question-answer artificial intelligence system

Michel‐Edwar Mickael, Marta Pajares, Ioana Enache, Gina Manda, Antonio Cuadrado

The paper presents a QAAI system for drug repurposing that identifies new indications for existing drugs using semantic AI and text mining, validated with in vitro experiments on zileuton and NRF2 pathway modulation.

bioRxiv · Apr 4, 2019 · PreprintNeuroscience

The Landscape Of Human Mutually Exclusive Splicing

Klas Hatje, Raza‐Ur Rahman, Ramon Oliveira Vidal, Dominic Simm, Björn Hammesfahr, Vikas Bansal, Ashish Rajput, Michel‐Edwar Mickael, Ting Sun, Stefan Bonn, Martin Kollmar

The paper estimates the extent and biological role of mutually exclusive splicing in humans by identifying and validating over 855 MXEs, including novel exons, and links them to disease pathology.

Molecular Systems Biology · Dec 1, 2017Peer-reviewedBioinformatics