Ting Sun

This paper identifies FABP8/PMP2 as a defining feature of human and old-world monkey CNS myelin, revealing molecular heterogeneity in myelin sheaths and its role in cholesterol enrichment.

KaroSpace provides a framework for interactive exploration of multi-sample spatial omics data, overcoming computational bottlenecks and proprietary software dependencies.

CD4+ T cells cross-reactive between Epstein-Barr virus EBNA1 and the central nervous system channel anoctamin-2 (ANO2) are elevated in multiple sclerosis and exacerbate experimental autoimmune encephalomyelitis in mice.

The paper identifies self-reactive B cells in atherosclerosis-associated tertiary lymphoid organs that produce high-affinity autoantibodies contributing to disease progression.

The paper shows oligodendrocytes contribute to amyloid-β plaques in Alzheimer's disease, but neurons are required for plaque formation.

The paper challenges the view that axonal degeneration in MS results from immune-mediated damage by proposing that myelin itself increases axonal degeneration risk under inflammatory conditions.

This study shows that ageing-related myelin dysfunction drives amyloid-beta deposition in Alzheimer's disease mouse models, suggesting myelin integrity as an upstream risk factor.

The paper compares myelin proteome and oligodendrocyte transcriptome profiles between humans and mice, finding both conservation and divergence in specific proteins and genes.

This study shows that CMTM5 deficiency in oligodendrocytes leads to progressive axonopathy, suggesting its role in maintaining axonal integrity rather than myelin formation.

The paper shows that neuronal cholesterol synthesis is critical for remyelination in chronic demyelination models and MS patients.

SEA provides a web tool for querying and analyzing small RNA expression across ten organisms, including differential expression and classification comparisons.

The paper estimates the extent and biological role of mutually exclusive splicing in humans by identifying and validating over 855 MXEs, including novel exons, and links them to disease pathology.