Cas1 mediates the interference stage in a phage-encoded CRISPR-Cas system
Laixing Zhang, Hao Wang, Jianwei Zeng, Xueli Cao, Zhengyu Gao, Zihe Liu, Feixue Li, Jiawei Wang, Yi Zhang, Maojun Yang, Yue Feng
This study identifies Cas1 as mediating the interference stage in a phage-encoded CRISPR-Cas system, revealing its role in connecting Cas2/3 to the DNA-bound Cascade complex.
Nature Chemical Biology · Jul 8, 2024Peer-reviewedMicrobiology