Nurat Affinnih

This study shows that Aβ42 accumulation increases excitatory and inhibitory synaptic transmission onto CA1 pyramidal cells and GLT-1 expression, which mediates its effects on cognition.

This study shows that neuronal glutamate transporter EAAC1 modulates synaptic excitation and lateral inhibition in D1-MSNs, affecting behavior through gain modulation and reduced firing sensitivity.

The paper shows circadian rhythms in hippocampal CA1 neurons and astrocytes affect synaptic plasticity through changes in NMDA receptor expression and astrocytic proximity to synapses, altering glutamate clearance and cognitive processing.