Annalisa Scimemi

This study reveals a previously unrecognized role of mGluRIII receptors in modulating GABA release onto pyramidal cells in hippocampal CA1 under physiological conditions.

This study shows that Aβ42 accumulation increases excitatory and inhibitory synaptic transmission onto CA1 pyramidal cells and GLT-1 expression, which mediates its effects on cognition.

This study shows that neuronal glutamate transporter EAAC1 modulates synaptic excitation and lateral inhibition in D1-MSNs, affecting behavior through gain modulation and reduced firing sensitivity.

NRN-EZ streamlines biophysical modeling of synaptic integration in NEURON by providing an interactive tool for specifying synaptic input patterns without requiring coding.

The paper estimates glutamate transporter surface density in mouse hippocampal astrocytes across ages and sub-cellular compartments, finding age-related changes and compartment-specific differences.

This study shows that brain-specific deletion of LRRC8A in mice leads to early mortality due to seizures, astrogliosis, and amino acid neurotransmitter dysregulation.

The paper develops in vitro neural ribbons from hiPSCs via neuromesodermal progenitors to generate spinal neurons and support cells, showing their survival and function in a rat SCI model.

The paper shows circadian rhythms in hippocampal CA1 neurons and astrocytes affect synaptic plasticity through changes in NMDA receptor expression and astrocytic proximity to synapses, altering glutamate clearance and cognitive processing.

The paper investigates how EAAC1 affects dopaminergic signaling and compulsive behaviors in mice by modulating mGluRI activation and D1R expression in the striatum.

This study uses non-linear modeling and bifurcation theory to show how global and local excitation/inhibition changes in MSNs control CSTC pathway dynamics, revealing that disproportionate changes can trigger oscillations.