Reduced LACTB expression in myeloid cells is associated with elevated succinylcarnitine levels and reduced Alzheimers disease risk.
Carmen Romero‐Molina, Ruben Gomez‐Gutierrez, Wen Yi See, Tulsi Patel, Hayk Davtyan, Jiacheng Ma, Quanyun Alan Xu, Michael Sewell, Kendra L. Allton, Morgan L. McReynolds, Olivia Calderon, Yaima Luzardo Lightfoot, Guido T. Bommer, Carlos Cruchaga, Mathew M. Blurton-Jones, , Alison Goate
The paper investigates the role of LACTB in Alzheimer's disease risk through Mendelian Randomization and experimental models, finding reduced LACTB expression lowers AD risk and increases succinylcarnitine levels.
bioRxiv · Mar 26, 2026 · PreprintNeuroscience