Author

Yaima Luzardo Lightfoot

The University of Texas MD Anderson Cancer CenterORCID 0009-0001-2153-1906Unclaimed ORCID profile · follow to get notified of new preprints

Biology Disciplines

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Neuroscience· 2

Signature Assays, Organisms & Methods

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Approach:experimental assay· 1 Research Focus:gene regulatory network inference· 1 Organism:human· 1 Organism:mouse· 1 Assay:proteomics· 1 Approach:statistical model· 1

Frequent Co-Authors

Alison GoateiD· 1 shared Audrey G. Reeves· 1 shared Carlos CruchagaiD· 1 shared Carmen Romero‐MolinaiD· 1 shared Connie HaiD· 1 shared David A. JoyiD· 1 shared David TatarakisiD· 1 shared Edoardo M. MarcoraiD· 1 shared

Activity by Year

2025-2026 · peak 1/yr

Co-Author Collaboration Network

10 top collaborators · 21 mutual co-author links

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1 shared paperNeuroscience

Alison GoateORCID

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2 papers

Recent·Most cited

Reduced LACTB expression in myeloid cells is associated with elevated succinylcarnitine levels and reduced Alzheimers disease risk.

Carmen Romero‐Molina, Ruben Gomez‐Gutierrez, Wen Yi See, Tulsi Patel, Hayk Davtyan, Jiacheng Ma, Quanyun Alan Xu, Michael Sewell, Kendra L. Allton, Morgan L. McReynolds, Olivia Calderon, Yaima Luzardo Lightfoot, Guido T. Bommer, Carlos Cruchaga, Mathew M. Blurton-Jones, , Alison Goate

The paper investigates the role of LACTB in Alzheimer's disease risk through Mendelian Randomization and experimental models, finding reduced LACTB expression lowers AD risk and increases succinylcarnitine levels.

bioRxiv · Mar 26, 2026 · PreprintNeuroscience

GPR34 regulates microglia state and loss-of-function rescues TREM2 metabolic dysfunction

Karthik Raju, David A. Joy, Sophia M. Guldberg, Kyla Germain, Neal S. Gould, Connie Ha, David Tatarakis, Jason C. Dugas, Sonnet S. Davis, Audrey G. Reeves, Shan V. Andrews, Tanya N. Weerakkody, Jung H. Suh, Gabrielly Lunkes de Melo, Ken Xiong, , Kathryn M. Monroe

This study shows that GPR34 regulates microglia function and loss-of-function in TREM2 KO microglia rescues cholesterol metabolism, suggesting GPR34 as a therapeutic target for Alzheimer's disease.

bioRxiv · Mar 28, 2025 · PreprintNeuroscience