Adrian Mejia-Santana

Disulfide bonds are required for cell division, cell envelope biogenesis and antibiotic resistance proteins in mycobacteria

The paper identifies cell envelope proteins in mycobacteria that require disulfide bonds for stability and shows that inhibiting the DsbA-VKOR pathway affects cell division and antibiotic resistance.

Warfarin analogs target disulfide bond-forming enzymes and suggest a residue important for quinone and coumarin binding

The paper identifies a conserved residue critical for quinone and coumarin binding in disulfide bond-forming enzymes and demonstrates the potential of warfarin analogs as anticoagulants or antibacterials.