Emma H. Doud

The paper investigates how EXOSC3 p.G191 variants affect RNA processing by analyzing transcriptomic, proteomic, and structural data in human cell models.

This study examines the molecular effects of aducanumab treatment in 5XFAD mice, revealing sex-dependent and IgG-mediated changes in amyloid and associated pathways.

This study identifies CaMKK2 as a dual-function regulator of chondrocyte proteostasis by scaffolding the UPS-Ubr4-19S proteasome complex and enhancing proteasome activity through Psmc5 phosphorylation.

This study shows that suppressing PP2A-B56α promotes EMT in EGFR mutant NSCLC by reducing epithelial markers and increasing mesenchymal markers, leading to migratory and invasive phenotypes.

This study shows that loss of Cathepsin K disrupts collagen biogenesis, ECM homeostasis, and actin polymerization in trabecular meshwork cells, potentially affecting aqueous humor outflow and IOP regulation.

This study identifies changes in non-histone lysine methylation during neuronal differentiation of LUHMES cells using quantitative proteomics.

This study shows that spinophilin enhances D2R interaction with cytosolic proteins, contributing to D2R agonist-induced locomotor suppression in Parkinson's disease.

This paper identifies PfAnchor as an essential protein for apicoplast fission and inheritance in Plasmodium falciparum, showing its interaction with PfDyn2 and its role in parasite survival.

The paper identifies cell envelope proteins in mycobacteria that require disulfide bonds for stability and shows that inhibiting the DsbA-VKOR pathway affects cell division and antibiotic resistance.

This study shows that activating PP2A-B56 in PDAC increases EGFR signaling and promotes tumor growth, suggesting a new therapeutic target.

This study shows that PP2A activation inhibits macropinocytosis and induces cell death in pancreatic ductal adenocarcinoma, suggesting PP2A activators could be used with metabolic inhibitors as a new therapeutic strategy.

This paper identifies VDAC1 as the target of SW016789, a hypersecretion inducer, and shows it causes distinct transcriptomic changes in beta-cells compared to ER stress.

The paper investigates how EXOSC3 S1-domain variants disrupt RNA exosome function, leading to altered rRNA processing and mRNA targeting.

The paper uses proteomics and PISA analysis to study PERK-dependent changes in protein homeostasis during ER stress induced by tunicamycin.

The paper uses ID-oPD to map spinophilin's interactome, identifying proteins involved in mRNA processing and translation, and suggests a role in synaptic protein expression.

The paper quantifies non-histone lysine methylation sites and lysine demethylases in breast cancer cell lines using TMT labeling without antibody enrichment, identifying differentially abundant sites and enzymes.

The paper compares BioID variants in budding yeast, identifies TurboID as the most effective, and explores the Ccr4-Not complex interactome.

This study identifies AZIN1 A-to-I editing as a marker of kidney recovery potential following inflammation.

This study investigates how prenatal methadone exposure affects protein and phosphoprotein levels in specific brain regions of mice, showing unique changes in the primary motor cortex linked to synaptic function.

The paper investigates the role of spinophilin in mediating mGluR5-dependent repetitive motor dysfunction in striatal neurons, showing subtype-specific effects on grooming behavior and synaptic plasticity.