Author

Li‐Fan Zeng

Indiana University IndianapolisORCID 0000-0002-3173-2744Unclaimed ORCID profile · follow to get notified of new preprints

Biology Disciplines

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Microbiology· 2 Neuroscience· 1 Physiology· 1

Signature Assays, Organisms & Methods

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Approach:experimental assay· 4 Research Focus:drug response / drug discovery· 2 Research Focus:host-pathogen & immune response· 2 Organism:human· 2 Organism:mouse· 2 Assay:proteomics· 2 Organism:bacteria (other)· 1 Organism:E. coli· 1

Frequent Co-Authors

Adrian Mejia-SantanaiD· 1 shared Akanksha AgrawaliD· 1 shared Alyssa M. Richards· 1 shared Anantha ShekhariD· 1 shared Anita C. Bellail· 1 shared Areli Jannes S. JavieriD· 1 shared B. J. Witek· 1 shared B. Zeidler· 1 shared

Activity by Year

2023-2026 · peak 1/yr

Co-Author Collaboration Network

10 top collaborators · 13 mutual co-author links

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1 shared paperMicrobiology

Adrian Mejia-SantanaORCID

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4 papers

Recent·Most cited

Empagliflozin preserves cardiac function and modulates metabolism in a mouse model of Duchenne muscular dystrophy

B. Zeidler, Connor R Thomas, John P. Salvas, Areli Jannes S. Javier, Alyssa M. Richards, Linda A. Bean, Conner C. Earl, Akanksha Agrawal, Niharika Narra, Li‐Fan Zeng, Carol A. Witczak, Joshua R. Huot, Il‐man Kim, Meena S. Madhur, Mark C. Kowala, , Steven S. Welc

This study shows empagliflozin improves cardiac function and mitochondrial health in a mouse model of Duchenne muscular dystrophy.

bioRxiv · Mar 14, 2026 · PreprintPhysiology

Pseudomonas aeruginosa phenazines dictate site-specific competitive interactions with Klebsiella pneumoniae

Katlyn Todd, Olivia Schneider, Joshua M. Lawrence, Josefina L Aronoff, B. J. Witek, Valerie Velazquez-Colon, Verónica Santana-Ufret, Moraima Noda, Ryan F. Relich, Li‐Fan Zeng, Dominique H. Limoli, Christopher Whidbey, Jay Vornhagen

This study shows that Pseudomonas aeruginosa uses phenazines to inhibit Klebsiella pneumoniae growth, with strain-specific and site-dependent effects.

bioRxiv · Aug 26, 2025 · PreprintMicrobiology

Warfarin analogs target disulfide bond-forming enzymes and suggest a residue important for quinone and coumarin binding

Dariana Chavez, Gwendolyn Nita Amarquaye, Adrian Mejia-Santana, Dyotima Dyotima, Kayley Ryan, Li‐Fan Zeng, Cristina Landeta

The paper identifies a conserved residue critical for quinone and coumarin binding in disulfide bond-forming enzymes and demonstrates the potential of warfarin analogs as anticoagulants or antibacterials.

Journal of Biological Chemistry · May 16, 2024Peer-reviewedMicrobiology

Molecular glue degraders enhance CAPRIN1-dependent lysosomal degradation of APP in Alzheimer disease

Sung Han Jung, Raktim N. Roy, Xu Wang, Bin Liu, Nancy Jaiswal, Ratan K. Rai, Yuichiro Takagi, Cen Gao, Li‐Fan Zeng, Ho-Yin Lo, Reagan K. Wohlford, Ryan K. Higgins, Anantha Shekhar, Anita C. Bellail, Chunhai Hao

The paper identifies molecular glue degraders that selectively degrade APP via CAPRIN1-dependent lysosomal pathway in neurons, reducing Aβ production in AD mouse models.

bioRxiv · Dec 29, 2023 · PreprintNeuroscience