How Ikaros and Aiolos homo- and heterodimers drive gene expression to ensure B cell development
Marie‐Céline Deau, Beate Heizmann, Adina Aukenova, Quentin Heydt, Patricia Marchal, Céline Charvet, Stéphanie Le Gras, Isabelle M. L. Billas, Dominic van Essen, Simona Saccani, Philippe Kastner, Susan H. Chan
This study identifies the distinct roles of Ikaros and Aiolos homo- and heterodimers in B cell development, showing they regulate different gene sets and functions through varied transcriptional mechanisms.
bioRxiv · Jun 9, 2025 · PreprintImmunology