Stéphanie Le Gras

This study shows PKA inhibits TRIM28-chromatin binding in ovarian granulosa cells, disrupting ovarian identity through SUMOylation dysregulation.

The paper identifies lin-15A as a Licenser that facilitates transdifferentiation by antagonizing identity safeguarding mechanisms in C. elegans.

The paper investigates sex differences in epigenetic changes linked to chronic pain-induced depression in mice, finding distinct genomic loci but shared regulatory features and gene modules across sexes.

This study shows that maternal high-fat diet during lactation accelerates tauopathy in THY-Tau22 mice, with sex-dependent effects where males are more affected earlier than females.

This study identifies the distinct roles of Ikaros and Aiolos homo- and heterodimers in B cell development, showing they regulate different gene sets and functions through varied transcriptional mechanisms.

This study shows that partially assembled TFIID complexes can initiate RNA polymerase II transcription but cannot fully replace holo-TFIID over time.

The paper shows that mitotic chromosome condensation resets transcriptional homeostasis by preventing unscheduled gene expression and transcriptional drift in the subsequent interphase.

This study identifies TRIM28's role in preventing female-to-male sex reversal in the adult mouse ovary by maintaining the ovarian pathway through SUMOylation.

This study identifies the dual role of sumoylation in adipocyte differentiation by regulating gene expression and transcriptional network rewiring through SLAMseq and ChIPseq.