Author

Jacob Miles

University of Massachusetts AmherstORCID 0000-0002-4242-785XUnclaimed ORCID profile · follow to get notified of new preprints

Biology Disciplines

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Microbiology· 2

Signature Assays, Organisms & Methods

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Assay:bulk RNA-seq· 2 Organism:human· 2 Research Focus:cell signaling & trafficking· 1 Research Focus:differential expression· 1 Approach:experimental assay· 1 Approach:statistical model· 1

Frequent Co-Authors

Mandy MulleriD· 2 shared Samantha Schultz· 2 shared Will Dwyer· 2 shared Daniel Macveigh-FierroiD· 1 shared Yahaira BermudeziD· 1 shared

Activity by Year

2025-2025 · peak 2/yr

Co-Author Collaboration Network

5 top collaborators · 9 mutual co-author links

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2 shared papersMicrobiology

Mandy MullerORCID

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2 papers

Recent·Most cited

MicrobiologybioRxivPreprintOct 2, 2025

Virally encoded interleukin-6 (vIL-6) coordinates with human IL-6 to modulate cytokine expression during KSHV infection

Yahaira Bermudez, Samantha Schultz, Jacob Miles…·Mandy Muller

This study shows that viral IL-6 (vIL-6) and human IL-6 work together to influence cytokine expression and immune responses during KSHV infection.

1 citation

humanbulk RNA-seq

𝕏 PostBluesky

MicrobiologybioRxivPreprintJun 5, 2025

IL-6 Evades KSHV-Mediated Hyperadenylation repression via CRM1-Dependent Nuclear Export.

Samantha Schultz, Jacob Miles, Will Dwyer…·Mandy Muller

The paper shows that IL-6 mRNA escapes KSHV-induced nuclear retention via CRM1-dependent export, bypassing SOX-mediated decay and maintaining cytoplasmic stability.

DOI 10.1101/2025.06.05.657986

humanbulk RNA-seq

𝕏 PostBluesky