AAV Ablates Neurogenesis in the Adult Murine Hippocampus
Stephen T. Johnston, Sarah Parylak, Stacy L. Kim, Nolan Mac, Christina K. Lim, Iryna S. Gallina, Cooper W Bloyd, Alexander Newberry, Christian D Saavedra, Ondřej Novák, J. Tiago Gonçalves, Fred H. Gage, Matthew Shtrahman
This study shows that rAAV causes dose-dependent cell death in adult murine hippocampal NPCs and DGCs, with no recovery of neurogenesis at 3 months.
eLife · Jul 14, 2021Peer-reviewedNeuroscience