Ondřej Novák

Longitudinal Imaging in a Mouse Model of Focal Cortical Dysplasia Reveals Lesion Expansion and Loss of Pre-Discharge Neuronal Recruitment

This study uses longitudinal imaging in a mouse model of FCD II to show lesion expansion, hypoactive dysmorphic neurons, and loss of pre-discharge neuronal recruitment over time.

High-frequency oscillations reveal progressive recruitment of remote cortex into the epileptic network in a mouse model of focal cortical dysplasia type II

The paper tracks how high-frequency oscillations evolve in a mouse model of focal cortical dysplasia type II, showing contralateral cortex recruitment into the epileptic network over time.

Chronic In Vivo Imaging of a Focal Cortical Dysplasia Mouse Model Reveals Progressive Neuronal Loss with No Senolytic or Antiseizure Efficacy Following Dasatinib-Quercetin Treatment

The paper tracks neuronal loss in an FCD mouse model and finds no reduction in seizures or neuron elimination with DQ treatment, suggesting strain-specific effects.

SEIZURE OCCURRENCE IN FCD TYPE II IS PREDICTED BY LESION POSITION AND LINKED TO CYTOARCHITECTURAL ALTERATIONS

This study investigates seizure occurrence in FCD type II by analyzing lesion position and cytoarchitectural changes in a mouse model.

Interictal activity fluctuations follow rather than precede seizures on multiple time scales in a mouse model of focal cortical dysplasia

Sensitivity optimization of a rhodopsin-based fluorescent voltage indicator

The paper identifies a mutation that enhances the sensitivity of a fluorescent voltage indicator, improving its ability to detect both spiking and subthreshold voltage signals in multiple organisms.

AAV Ablates Neurogenesis in the Adult Murine Hippocampus

This study shows that rAAV causes dose-dependent cell death in adult murine hippocampal NPCs and DGCs, with no recovery of neurogenesis at 3 months.

A fast genetically encoded fluorescent sensor for faithful in vivo acetylcholine detection in mice, fish, worms and flies

iAChSnFR, a fluorescent indicator built from a bacterial periplasmic binding protein, reports acetylcholine with large, fast signals in mouse, fish, fly and worm preparations.

Bright and photostable chemigenetic indicators for extended in vivo voltage imaging

The paper introduces a new genetically encoded voltage indicator, Voltron, which improves brightness and photostability for extended in vivo voltage imaging in mice, zebrafish, and fruit flies.

Kilohertz frame-rate two-photon tomography

This paper introduces a two-photon imaging technique that achieves high-speed, high-resolution imaging of neural activity in mice at over 1 kHz frame rates.

A genetically encoded fluorescent sensor for in vivo imaging of GABA

This paper develops a genetically encoded fluorescent sensor, iGABASnFR, to monitor GABA in vivo and demonstrates its use in tracking GABA dynamics in various neural contexts.

Thy1 transgenic mice expressing the red fluorescent calcium indicator jRGECO1a for neuronal population imaging in vivo

The paper presents transgenic mice expressing the red calcium indicator jRGECO1a for in vivo neuronal imaging, showing comparable or better signal-to-noise ratios than viral methods.