J. Tiago Gonçalves

This study demonstrates the use of engineered microglia to deliver BDNF to the adult mouse brain, controlled by doxycycline, with enhanced engraftment via a constitutively active CSF1R mutant.

This study shows human glioblastoma cells integrate into brain-wide neuronal circuits, exhibit diverse connectivity, and respond to neuromodulatory inputs like acetylcholine, which promotes invasion and survival.

This study shows that adult neurogenesis in mice enhances spatial information encoding in the hippocampus during novel context exposure.

This study shows that aged mice have impaired spatial representations in the hippocampal dentate gyrus for novel environments, but these improve with repeated exposure, while hyperexcitability does not disrupt familiar environments.

This study identifies Klf9 as a transcriptional regulator that suppresses symmetric self-renewal of radial-glial neural stem cells in the adult hippocampus.

This study shows that including vascular cells with neural precursor cells improves graft survival and vascularization after stroke.

The paper shows that silencing hippocampal output impairs spatial reward search using spatial cues but not local cues in a treadmill task.

This study shows that rAAV causes dose-dependent cell death in adult murine hippocampal NPCs and DGCs, with no recovery of neurogenesis at 3 months.

The paper tests the E/I imbalance model in Fragile X syndrome using computational modeling and 2-photon imaging data, finding it insufficient and revealing stage-dependent circuit changes.