Author

Christina K. Lim

Salk Institute for Biological Studies

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

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Neuroscience· 5

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Approach:experimental assay· 4 Organism:mouse· 4 Organism:human· 2 Assay:bulk RNA-seq· 1 Research Focus:differential expression· 1 Approach:statistical model· 1

Frequent Co-Authors

Fred H. GageiD· 5 shared Iryna S. Gallina· 3 shared Sarah ParylakiD· 3 shared Aidan H. McDonald· 2 shared Joshua M. PrattiD· 2 shared Alexander Newberry· 1 shared Ariana L. Tucker· 1 shared Ava KatziD· 1 shared

Activity by Year

2021-2026 · peak 2/yr

Co-Author Collaboration Network

10 top collaborators · 30 mutual co-author links

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5 shared papersNeuroscience

Fred H. GageORCID

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5 papers

Recent·Most cited

Impaired lipoprotein secretion by APOE4 leads to lysosomal and mitochondrial dysfunction in human microglia

Jasmin S. Revanna, Karl A. Wessendorf-Rodriguez, Qiang Xiao, Thaís S. Sabedot, Michael S. Cuoco, Snigdha Sarkar, Lucia Zhou-Yang, Christina K. Lim, Victoria N. Prozapas, Rowan S. Wooldridge, Jean Paul Chadarevian, Joshua M. Pratt, Sheila C. Steiner, Ava Katz, Jérôme Mertens, , Fred H. Gage

This study shows that APOE4 impairs lipoprotein secretion in microglia, leading to lysosomal and mitochondrial dysfunction and a proinflammatory phenotype.

bioRxiv · May 13, 2026 · PreprintNeuroscience

AGO1 in neural progenitor cells orchestrates brain development and sociability via LIN28A-REELIN axis

Hyunsu Do, Dayeon Kim, Roberto Jappelli, Hyeokjun Yang, Yi-Seon Jeon, Geurim Son, Mingyu Ju, Ji-Hoon Son, Insook Ahn, Christina K. Lim, Jeong-Seon Ji, Jihae Lee, Young‐Kook Kim, Joon‐Yong An, Seung‐Hee Lee, , Jinju Han

This study identifies AGO1's role in neural progenitor cells in brain development and sociability through the LIN28A-REELIN axis, showing its impact on ASD-related phenotypes.

bioRxiv · Oct 1, 2025 · PreprintNeuroscience

CK2 inhibition suppresses glial inflammation in the brain

Ioana I. N. Da Silva, Desiree Ramirez, Sarah Parylak, Leslie A. Wallace, James K. Tucker, Joel M. Erberich, Rutvi Katariya, Aidan H. McDonald, Iryna S. Gallina, Ariana L. Tucker, Jillybeth Burgado, Baptiste N. Jaeger, Jerika J. Barron, Joshua M. Pratt, Monique Pena, , Fred H. Gage

This study identifies CK2 as a key driver of glial inflammation in neurodegenerative disorders and shows that its inhibition reduces inflammation in AD models.

bioRxiv · Aug 5, 2025 · PreprintNeuroscience

Neuronal activity-related transcription is blunted in immature compared to mature dentate granule cells

Sarah Parylak, Fan Qiu, Sara B. Linker, Iryna S. Gallina, Christina K. Lim, David Preciado, Aidan H. McDonald, Xavier Zhou, Fred H. Gage

The paper shows that immature dentate granule cells exhibit reduced transcriptional responses to spatial exploration compared to mature cells.

Hippocampus · Feb 22, 2023Peer-reviewedNeuroscience

AAV Ablates Neurogenesis in the Adult Murine Hippocampus

Stephen T. Johnston, Sarah Parylak, Stacy L. Kim, Nolan Mac, Christina K. Lim, Iryna S. Gallina, Cooper W Bloyd, Alexander Newberry, Christian D Saavedra, Ondřej Novák, J. Tiago Gonçalves, Fred H. Gage, Matthew Shtrahman

This study shows that rAAV causes dose-dependent cell death in adult murine hippocampal NPCs and DGCs, with no recovery of neurogenesis at 3 months.

eLife · Jul 14, 2021Peer-reviewedNeuroscience